Junctural Alignment in Kyoto Japanese Compound Nouns

Descriptively, in Tokyo Japanese compound words whose second member measures up to four moras in length, compound accent is placed on the syllable immediately preceding or following the boundary, or "juncture," between compound members. The length of the second member of the compound determines which of the two possible syllables is accented. Kubozono (1995) proposes an analysis with a constraint which requires that compound accent be aligned with the juncture. However, Ito and Mester (2018) account for compound accent location without reference to the juncture.Kyoto Japanese compound accent placement is similar to that of Tokyo Japanese (Nakai 2002) with a crucial difference: compound accent is placed on the mora, not the syllable, immediately preceding or following the juncture. This results in a discrepancy in which compound accent is placed on the first mora of a heavy syllable in some cases and on the second mora of a heavy syllable in other cases. I demonstrate that this discrepancy makes alignment to the juncture indispensable for Kyoto Japanese and that general left and right alignment constraints relativized to three levels of recursive word (maximal, minimal, any) cannot by themselves place compound accent in the correct location in all cases

Metabolic and functional consequences of cytosolic 5′-nucleotidase-IA overexpression in neonatal rat cardiomyocytes

Adenosine exerts a spectrum of energy-preserving actions on the heart negative chronotropic effects. The pathways leading to adenosine formation have remained controversial. In particular, although cytosolic 5′-nucleotidases can catalyze adenosine formation in cardiomyocytes, their contribution to the actions of adenosine has not been documented previously. We recently cloned two closely related AMP-preferring cytosolic 5′-nucleotidases (cN-IA and -IB); the A form predominates in the heart. In this study, we overexpressed pigeon cN-IA in neonatal rat cardiomyocytes using an adenovirus. cN-IA overexpression increased adenosine formation and release into the medium caused by simulated hypoxia and by isoproterenol in the absence and presence of inhibitors of adenosine metabolism. Adenosine release was not affected by an ecto-5′-nucleotidase inhibitor, α,β-methylene-ADP, but was affected by a nucleoside transporter, dipyridamole. The positive chronotropic effect of isoproterenol (130 ±3 vs. 100 ±4 beats/min) was inhibited (107 ±3 vs. 94 ±3 beats/min) in cells overexpressing cN-IA, and this was reversed by the addition of the adenosine receptor antagonist 8-(p-sulfophenyl)theophilline (120 ± 3 vs. 90 ± 4 beats/min). Our results demonstrate that overexpressed cN-IA can be sufficiently active in cardiomyocytes to generate physiologically effective concentrations of adenosine at its receptors.Fil: Sala-Newby, Graciela B.. University of Bristol; Reino UnidoFil: Freeman, Nicola V. E.. University of Bristol; Reino UnidoFil: Curto, Maria de Los Angeles. University of Bristol; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Newby, Andrew C.. University of Bristol; Reino Unid

Robotic-Assisted Laparoscopic Gynecologic Procedures in a Fellowship Training Program

An early evaluation of the feasibility of training fellows in robotic surgery suggests that it is feasible to incorporate a systematic approach to robotic-assisted laparoscopic training at the onset of incorporating this technology into current practice

Stellar energy loss rates beyond the standard model

It is known that the dipolemoments of the neutrino lead to important astrophysical and cosmological effects. In this regard, within the context of a U(1)B−L model, we develop and present novel analytical formulas to assess the effects of the anomalous magnetic moment and electric dipole moment of the neutrino on the stellar energy loss rates through some common physical process of pair-annihilation e+e− → (γ, Z, Z ) → ν¯ν. Our results show that the stellar energy loss rates strongly depend on the effective magnetic moment of the neutrino, but also on the parameters which characterize the adopted U(1)B−L mode

A search for stellar tidal streams around Milky Way analogues from the SAGA sample

© The Authors 2023. We want to thank to Yao-Yuan Mao, Marla Geha and Risa Wechsler for providing the original SAGA sample for this paper and useful comments. We also thank Dustin Lang and John Moustakas for running the modified Legacypipe code to produce the images used here. DMD acknowledges financial support from the Talentia Senior Program (through the incentive ASE-136) from Secretaría General de Universidades, Investigación y Tecnología, de la Junta de Andalucía. DMD acknowledges funding from the State Agency for Research of the Spanish MCIU through the “Center of Excellence Severo Ochoa” award to the Instituto de Astrofísica de Andalucía (SEV-2017- 0709) and project (PDI2020-114581GB-C21/ AEI / 10.13039/501100011033). MAGF acknowledges financial support from the Spanish Ministry of Science and Innovation through the project PID2020-114581GB-C22. SRF acknowledges financial support from the Spanish Ministry of Economy and Competitiveness (MINECO) under grant number AYA2016-75808-R, AYA2017-90589- REDT and S2018/NMT-429, and from the CAM-UCM under grant number PR65/19-22462. SRF acknowledges support from a Spanish postdoctoral fellowship, under grant number 2017-T2/TIC-5592. APC is supported by the Taiwan Ministry of Education Yushan Fellowship and Taiwan National Science and Technology Council grant 109-2112-M-007-011-MY3. The photometry analysis in this work was partly done using GNU Astronomy Utilities (Gnuastro, ascl.net/1801.009) version 0.17. Work on Gnuastro has been funded by the Japanese MEXT scholarship and its Grant-in-Aid for Scientific Research (21244012, 24253003), the European Research Council (ERC) advanced grant 339659-MUSICOS, and from the Spanish Ministry of Economy and Competitiveness (MINECO) under grant number AYA2016-76219-P. The Leiden Observatory has provided facilities and computer infrastructure for carrying out part of this work. MA acknowledges the financial support from the Spanish Ministry of Science and Innovation and the European Union - NextGenerationEU through the Recovery and Resilience Facility project ICTS-MRR-2021-03-CEFCA.Context. Stellar tidal streams are the result of tidal interactions between a central galaxy and lower mass systems such as satellite galaxies or globular clusters. For the Local Group, many diffuse substructures have been identified and their link to the galaxy evolution has been traced. However, it cannot simply be assumed that the Milky Way or M 31 are representative of their galaxy class. Thus, a larger sample of analogue galaxies beyond the Local Group is required to bolster a broader generalisation of the underlying theory. Aims. We want to detect and photometrically characterise stellar streams around Milky Way (MW-) analogues in the local Universe in order to extend the observational evidence of interactions between this class of host galaxies and their satellites. This information will be applicable in a more general context around future studies on galaxy formation and evolution processes. Methods. In the present work, we identified and analysed stellar tidal streams around MW-analogue galaxies from the SAGA sample, using deep images of the DESI Legacy Imaging Surveys. For this sample, we obtained a range of r-band surface brightness limit between 27.8 and 29 mag arcsec^(−2) . We measured the surface brightness and colours of the detected streams using GNU Astronomy Utilities software. Results. We identified 16 new stellar tidal streams around MW-analogue galaxies at distances between 25 and 40 Mpc. In applying a statistical analysis to our findings for the SAGA II galaxy sample, we obtained a frequency of 12.2% ± 2.4% for these stellar streams. We measured the surface brightness and colours of the detected streams and carried out a comparison to the dwarf satellite galaxies population around galaxies belonging to the same SAGA sample. We show that the mean colour of the streams is 0.20 mag redder than that of the SAGA satellites; in addition, the streams are, on average, 0.057 ± 0.021 mag redder that their progenitor (for cases where a likely progenitor could be identified). Conclusions. The frequency of streams detected around MW-analogues in the Local Universe is in agreement with previous studies. The difference in colour between detected streams and satellites within the SAGA host galaxy sample could be explained by a combination of both selection biases in the SAGA study and physical processes.Depto. de Física de la Tierra y AstrofísicaFac. de Ciencias FísicasTRUETalentia Senior Program (through the incentive ASE-136) from Secretaría General de Universidades, Investigación y Tecnología, de la Junta de AndalucíaCentro de Excelencia Severo OchoaMinisterio de Ciencia, Innovación y Universidades (MCIU)Ministerio de Economía y Competitividad (MINECO)CAM-UCMSpanish postdoctoral fellowshipTaiwan Ministry of Education Yushan FellowshipTaiwan National Science and Technology CouncilJapanese MEXT scholarshipEuropean Research Council (ERC)European Union - NextGeneration through the Recovery and Resilience Facility projectInstituto de Astrofísica de Andalucíapu

Treatment Burden of Weekly Somatrogon vs Daily Somatropin in Children With Growth Hormone Deficiency: A Randomized Study

Context: Somatrogon is a long-acting recombinant human growth hormone treatment developed as a once-weekly treatment for pediatric patients with growth hormone deficiency (GHD). / Objective: Evaluate patient and caregiver perceptions of the treatment burden associated with the once-weekly somatrogon injection regimen vs a once-daily Somatropin injection regimen. / Methods: Pediatric patients (≥3 to <18 years) with GHD receiving once-daily somatropin at enrollment were randomized 1:1 to Sequence 1 (12 weeks of once-daily Somatropin, then 12 weeks of once-weekly somatrogon) or Sequence 2 (12 weeks of once-weekly somatrogon, then 12 weeks of once-daily Somatropin). Treatment burden was assessed using validated questionnaires completed by patients and caregivers. The primary endpoint was the difference in mean overall life interference (LI) total scores after each 12-week treatment period (somatrogon vs Somatropin), as assessed by questionnaires. / Results: Of 87 patients randomized to Sequence 1 (n = 43) or 2 (n = 44), 85 completed the study. Once-weekly somatrogon had a significantly lower treatment burden than once-daily Somatropin, based on mean overall LI total scores after somatrogon (8.63) vs Somatropin (24.13) treatment (mean difference -15.49; 2-sided 95% CI -19.71, -11.27; P < .0001). Once-weekly somatrogon was associated with greater convenience, higher satisfaction with treatment experience, and less LI. The incidence of treatment-emergent adverse events (TEAEs) for Somatropin and somatrogon was 44.2% and 54.0%, respectively. No severe or serious AEs were reported. / Conclusion: In pediatric patients with GHD, once-weekly somatrogon had a lower treatment burden and was associated with a more favorable treatment experience than once-daily Somatropin

Photocatalytic proton reduction by a computationally identified, molecular hydrogen-bonded framework

We show that a hydrogen-bonded framework, TBAP-α, with extended π-stacked pyrene columns has a sacrificial photocatalytic hydrogen production rate of up to 3108 μmol g-1 h-1. This is the highest activity reported for a molecular organic crystal. By comparison, a chemically-identical but amorphous sample of TBAP was 20-200 times less active, depending on the reaction conditions, showing unambiguously that crystal packing in molecular crystals can dictate photocatalytic activity. Crystal structure prediction (CSP) was used to predict the solid-state structure of TBAP and other functionalised, conformationally-flexible pyrene derivatives. Specifically, we show that energy-structure-function (ESF) maps can be used to identify molecules such as TBAP that are likely to form extended π-stacked columns in the solid state. This opens up a methodology for the a priori computational design of molecular organic photocatalysts and other energy-relevant materials, such as organic electronics